Sentence examples for a substantial dose dependent from inspiring English sources

Addition of heparanase to the culture medium resulted in a substantial, dose dependent decrease in ConA activation and proliferation of the spleen cells (Fig. 3A).

We co-expressed Aurora-A (1 µg) with different amounts of PUM2, and immunoblotting analysis revealed that the increase in the protein amount of Aurora-A was accompanied by a substantial dose dependent increase in the steady-state protein amount of PUM2 (Figure 3A).

Similarly, primary cultures of glial cells transduced with the Lv-shVIM vector presented a substantial, dose-dependent decrease in vimentin levels with respect to the control vector (Fig. 2C).

HuH7 cells treated with BIO showed a substantial, dose-dependent increase in TCF/LEF reporter activity.

Exposing cultured PBMCs to either GOS or GOS/FOS fractions resulted in a substantial dose-dependent increase of tumour necrosis factor-α (TNF-α) production in LPS challenged PBMCs.

EPO administration led to substantial dose-dependent reduction in S100B following CO poisoning in an animal model [ 51].

In contrast, BEZ235 treatment resulted in substantial dose-dependent accumulation in the G0-G1 phase of the cell cycle.

The loss of CXCR4+ cells due to drug exposure showed substantial dose-dependent loss of CXCR4+ cells following treatment with agents 5-FU, Ox, Vin, Cis, MTX and SN-38 at the concentrations tested (Fig.  1a, Additional file 1: Figure S1a).

The programs include a substantial dose of business strategy, too.

Besides the cost, the cleanup will expose plant workers to a substantial dose of radiation.

In immunology, parts-per-billion is a substantial dose.