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The phrase "a substantial distinction between" is correct and usable in written English.
You can use it when discussing differences or contrasts between two or more items, concepts, or ideas.
Example: "There is a substantial distinction between the two theories regarding climate change."
Alternatives: "a significant difference between" or "a marked contrast between".
Exact(2)
It may be conceded, as a general proposition, that there is a substantial distinction between the acts of a municipality as the agent of the state, for the preservation of peace and the protection of persons and property, and its acts as the agent of its citizens, for the care and improvement of the public property, and the adaptation of the city for the purposes of residence and business.
His account required a substantial distinction between logical form and grammatical form as traditionally conceived.
Similar(58)
In the European Court of Human Right's case law, a substantial distinction is thus made between the choices of justification when processing sensitive data.
Except there is a substantial distinction in the small print.
That the distinction between constitutive and instantiated properties makes no sense in the case of "the mover moves" shows that there is no substantial distinction between these properties, and that the conceptualization of a situation in terms of these is purely a result of cognitive convenience.
I see no substantial distinction between the two dispositions.
I make a strong distinction between death and dying.
There's a strong distinction between happiness and fun.
Others made a strong distinction between thinking and acting.
The chapter makes clear the substantial distinctions between design conditions for optical and RF applications, namely, the presence of nonlinear distortions in the optical fiber communication channel.
Because of the substantial distinctions between the two, brokers and real estate lawyers advise buyers to hire an experienced landlord-tenant lawyer at the outset of the purchase process.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com