The phrase "a substantial disruption of" is correct and usable in written English.
It can be used when discussing significant interruptions or disturbances in various contexts, such as events, processes, or systems.
Example: "The storm caused a substantial disruption of public transportation services, leaving many commuters stranded."
Alternatives: "a significant interruption of" or "a major disturbance of".
But students circulating petitions or holding signs aren't any rational person's idea of a substantial disruption.
She went on to say that "it is believed that this posting also has a reasonable expectation that it will cause a material and/or substantial disruption of school activities and/or be constituted as a threat".
They agreed that the song caused a "substantial disruption" at the school.
31P NMR spectra obtained from POPC/POPG (3:1) bilayers containing LL7-27 substantialntial disruption of the lipid bilayer structure and agree with the peptide's ability to induce dye leakage from POPC/POPG (3:1) vesicles.
"Money has been provided for water and sanitation… The substantial disruption of living conditions caused by the earthquake no longer exist".
In declaring most of the campus a "non-public forum" and in limiting petitioning, pamphleting and protesting to the designated free-speech area, it cites the need to prevent "substantial disruption of the orderly operation of the college".
Further enhancements can apply if the offender evidenced an intent to carry out the threat (6-level enhancement); made more than two threats (2-level enhancement); caused substantial disruption of public, governmental, or business functions or services (4-level enhancement); or created a substantial risk of inciting others to harm federal officials (2-level enhancement).
In December 2011 BART adopted a new "Cell Service Interruption Policy" that only allows shutdowns of cell phone services within BART facilities "in the most extraordinary circumstances that threaten the safety of District passengers, employees and other members of public, the destruction of District property, or the substantial disruption of public transit service".
HIV infection causes dramatic damage to the gastrointestinal (GI) tract, that includes substantial disruption of gut microbiota composition with presence of microbes at higher pathogenic potential compared to less aggressive indigenous organisms, massive loss of gut-residing CD4+ T-cells, and down-regulation of GI tract genes expression [1], [2], [3].
