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Discover LudwigThe phrase "a substantial disintegration" is correct and usable in written English.
It can be used to describe a significant breakdown or deterioration of something, whether physical, structural, or metaphorical.
Example: "The building suffered a substantial disintegration after the earthquake, leaving it in ruins."
Alternatives: "a significant breakdown" or "a major collapse."
Exact(1)
It is seen that an exposure to water vapor leads to a substantial disintegration of the spinel structure into a variety of locally different structures that all exhibit a diffuse [211] diffraction pattern, which is indistinguishable from the one shown in Fig. 7a.
Similar(59)
Using a precise sense of cutting and framing to describe the disintegration of a group of college friends threatened by a flesh-eating virus, "Cabin Fever" promises to be the beginning of a substantial Hollywood career.
We made a substantial bid.
A substantial and satisfying volume.
This is a substantial upgrade".
A substantial irony enters here.
That is a substantial amount.
This is a substantial grievance.
A Substantial Drink Problem.
A substantial hole.
We need a substantial break with tradition.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com