Another study, in a commercial health plan population during the period of 2006 2008, reported substantial discontinuation, restarting, and switching among new users of various anti-osteoporosis medications [ 29].
Substantial discontinuation of use of Mirena was noted and makes interpretation of findings for this treatment difficult.
Overall a substantial proportion of treatment discontinuation in the first few months is due to adverse effects of medication [ 1].
Premature TB treatment discontinuation remains a substantial problem in 11 districts in Bihar especially among individuals who repeatedly seek TB care.
Although the latter two side effects are usually mild, they are persistent, can lead to treatment discontinuation and have a substantial negative impact on a patient's quality of life.
To test the possibility that the high discontinuation rate introduced a substantial bias, we compared participants and nonparticipants with respect to baseline data and changes at 1, 3, and 6 months after diet initiation (Supplementary Table 1).
If risks observed after lithium discontinuation relate directly to discontinuing lithium, this finding would appear consistent with a substantial literature documenting pronounced suicide risks upon lithium discontinuation (e.g., suicide rates up to 14-fold greater than during the preceding lithium treatment) [ 11, 12, 33].
One patient treated with fluvoxamine who suffered from fatigue for many years prior to inclusion in the present trial reported a substantial improvement in fatigue during treatment, and a subsequent deterioration after treatment discontinuation.
It could be argued that a substantial proportion of patients remain relapse-free even 12 months after treatment discontinuation, and that these patients may not require continuous antipsychotic treatment.
The MDP301 protocol included a substantial social science component and the application of these qualitative techniques during the discontinuation period was critical in informing operational procedures.
