The phrase "a substantial difficulty in" is correct and usable in written English.
It can be used when discussing challenges or obstacles encountered in a particular situation or context.
Example: "The team faced a substantial difficulty in meeting the project deadline due to unforeseen circumstances."
Alternatives: "a significant challenge in" or "a considerable obstacle in".
A major drawback has been the substantial difficulty in designing HIF-specific inhibitors owing to the intracellular nature of the protein complex and the lack of active sites to which small molecular inhibitors are usually designed (Scheuermann et al., 2013).
It appears then that patients in stage 1 of the disease as a result of mild symptoms do not have substantial difficulty in their daily lives.
From April next year, councils have to offer advocacy services for people who have "substantial difficulty" in being fully involved in decision-making, and who don't have an appropriate person to support them.
Program for Survivors of Torture and Physicians for Human Rights, we found that more than half of the individuals we interviewed with serious health problems reported substantial difficulty in accessing care.
Fortunately there is no substantial difficulty in formulating neural field models on curved surfaces, though to date there has been surprisingly little analysis of spatio-temporal pattern formation in this context.
Introduction: Out of hospital cardiac arrest (OHCA) patients treated with targeted temperature management (TTM) may have substantial difficulty in ventilator weaning due to multiple organ failure, including post-TTM neurologic injury.
Garvin-Doxas and Klymkowsky (2008) reported that substantial difficulty in understanding molecular and evolutionary biology is associated with deep-seated misconceptions about random processes, noting that students believe that random processes are inefficient, whereas they regard biological systems as very efficient.
Adding accurate laboratory testing data to ILI addresses the otherwise substantial difficulty in estimating ILI consultations due to influenza, and results in estimates that are less sensitive to parameter misspecification.
In 2004, young women in Maputo demonstrated substantial difficulty in assessing their own risk even when they had correct knowledge about HIV transmission [ 8]. High risk activities, among both men and women, may be encouraged by local traditions and customs [ 9].
This finding adds to the explanation as to why previous studies had substantial difficulties in demonstrating a specific meteorological condition serving as a trigger factor of migraine attacks, especially in studies that analyzed a complete population without performing individual analyses for all study participants.
Any change or addition to the physics model would require a reformulation of the adjoint problem and substantial difficulties in its software implementation.
