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The phrase "a substantial difference that" is correct and usable in written English.
It can be used when discussing a significant distinction or variation between two or more subjects or ideas.
Example: "There is a substantial difference that affects the overall outcome of the experiment."
Alternatives: "a significant difference that" or "a considerable difference that".
Exact(1)
Although WSNs are sometimes thought of as a special case of wireless ad hoc networks, they present a substantial difference, that is, nodes are at least of two different types: sensor and sink nodes.
Similar(59)
These results confirm the substantial difference that exists between great apes and dogs with regard to mental representation abilities required to track the invisible displacements of objects.
Although similarities are evident in this cluster, a deeper analysis revealed substantial differences that will be discussed in the next sections.
The main critical points highlighted by these authors (Barton 2004; Lapsley et al. 2009) can be attributed to topics of a technical nature or to the substantial differences that exist between public and private sectors.
Whilst differences may appear rather small over a decade, they can accumulate to contribute substantial differences that may dramatically affect the timing of harvests which is typically influenced by the number of stems exceeding some threshold.
Using tetranucleotide (TNS) and hexanucleotide (HNS) signature analysis we find that, while in some instances there is significant overlap between the genes identified using the different component lengths, there are substantial differences that indicate additional horizontally transferred genes not identified by DNS alone (Tables 2 to 6).
Together with a large number of previously determined prefusion structures of influenza A and B virus HA and a postfusion structure of influenza A/H3N2 HA2, we identified conserved features that are shared between influenza A and B virus HA in the conformational transition and documented substantial differences that likely influence the detailed mechanisms of this process.
As a result, isolates that are considered to have identical SCCmec might have substantial differences that are unrecognized.
"Aspiring librettists can study music-theater writing on the graduate level, but their work will draw overwhelmingly from the commercial and nonprofit theater, leaving unexamined the substantial differences that remain between the theater and the opera house".
This physical separation is consistent with the substantial differences that have accumulated between MaSp1 and MaSp2.
Many genes were selected by only one of the platforms, indicating that the parametric framework does not account for other substantial differences that exist between platforms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com