The phrase "a substantial difference of" is correct and usable in written English.
It can be used when discussing a significant variation or distinction between two or more items, concepts, or situations.
Example: "There is a substantial difference of opinion among the experts regarding the best approach to climate change."
Alternatives: "a significant difference in" or "a considerable disparity between".
On the other hand, a substantial difference of crystallization behaviors was observed between these two samples.
"What you're talking about with the current president is a substantial difference of degree in which some of these things happen.
A substantial difference of these parameters observed for the various Dx/CL systems was explained by the effect of nature of crosslinking agents on the mechanism of crosslinking and swelling processes.
"Finally, it is no secret that there is a substantial difference of opinion regarding the science of EPA's recent Bristol Bay Assessment.
There's a substantial difference of opinion between the man who runs Golden Boy Promotions and the former world-champion boxer the Los Angeles-based company is named after.
It is unlikely that a substantial difference of expertise is present across operative surgeons.
Our study indicates that the inclusion of types 1 and 5 will make a substantial difference to the efficacy of the vaccine in Malawi.
With an average cost per enrollment of around one US dollar, UIDAI has demonstrated that a substantial difference to the lives of a population can be made at a cost that is truly manageable.
Having direct access to open space - a balcony, terrace or roof area - makes a substantial difference to the quality of everyday life.
It was the largest economic infrastructure investment in the country since the second world war, and has made a substantial difference to the quality of life on South Tarawa.
"There are many other examples but just those four things would make a substantial difference to the lives of asylum seekers and have to be respected as being really clear differences between the two parties.
