The phrase "a substantial difference in age" is correct and usable in written English.
It can be used when discussing the age gap between individuals, often in contexts related to relationships, demographics, or social studies.
Example: "There is a substantial difference in age between the two actors, which adds an interesting dynamic to their on-screen chemistry."
Alternatives: "a significant age gap" or "a considerable age difference."
We detected a substantial difference in the age at presentation between the two ethnic groups.
(It does not seem unreasonable to assume that this is what Lilford meant as he suggested that age should be used as a tie-breaker... 'if the only distinguishing feature was a substantial difference in their ages.') However, they cannot be and it is a misleading distraction to suggest that they can.
However, the lack of a substantial difference in anxiety between women aged 20 29 and women aged 30 39 suggests that our results are not driven by the effect of first smears.
Specifically, there was a substantial difference in overall performance between age groups such that adult participants performed close to ceiling (the average of same-aligned and same-misaligned was 92% [18] and 93% [19]) while children's performance was placed nicely in the middle of the 2AFC 50–100 range (82% [18] and 77% [19]).
Our study showed that there was a substantial difference in oseltamivir use among age groups.
The substantial difference in age effect between GBM and non-GBM suggests a fundamental difference in the genesis of primary GBM (the driver of GBM incidence) versus non-GBM.
Only unaffected carriers over the age of 60 were used for gene array experiments, since they had the least probability of later developing later disease, and would still have substantial difference in age of onset if they did harbor occult disease.
Age- and length-based systems had a substantial difference in over- and underestimation of weight in high-income and low- and middle-income populations.
The age class breakdown for Δ t presented in Figure 1B shows a substantial difference in response between children and adult subgroups during the intervention period.
