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The phrase "a substantial difference between" is correct and usable in written English.
It can be used when discussing or comparing two or more items, concepts, or situations to highlight a significant distinction.
Example: "There is a substantial difference between the two approaches to problem-solving, which can lead to varying outcomes."
Alternatives: "a significant difference between" or "a marked difference between".
Exact(60)
However, it is still debated whether there is a substantial difference between contrast media with different osmolality being in the literature present conflicting data.
There's a substantial difference between the two".
For each parameter, there was a substantial difference between the sexes.
Yet students of Whitehall observe a substantial difference between what Thatcher said and Blair has done.
But there was a substantial difference between those days and these.
When Xygalatas and his colleagues analyzed the donations to Murugan's temple, they found a substantial difference between the groups.
"There is not a substantial difference between Coca-Cola and Pepsi-Cola except in the brand image".
There's a substantial difference between finishing third and bottom," Kidney said.
But there is a substantial difference between sensible enterprise and pointless expansion.
I think there's a substantial difference between 'Too hot' and 'hot', and if you can get that clear in your head, that leads to a series of thoughts".
"It became quite evident to us," Idzik said, "that there was a substantial difference between Darrelle's view of his value and ours".
More suggestions(20)
a remarkable difference between
a large difference between
a notable difference between
a sizeable difference between
a major difference between
a massive difference between
a noticeable difference between
a considerable difference between
a tremendous difference between
a great difference between
a huge difference between
a substantive difference between
a crucial difference between
a serious difference between
a sizable difference between
a fundamental difference between
a substantial discrepancy between
a substantial tradeoff between
a substantial overlap between
a substantial concordance between
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com