First, it is the first substantial demonstration of a dysglycaemic effect of statin treatment among patients with existing diabetes.
Substantial demonstration and other risk absorption schemes will have to be developed to shift technical risks to society at large.
There was, however, a substantial counter-demonstration by other students who loudly cheered the royal party and waved "welcome" placards.
It was a real demonstration of power.
"There will be substantial demonstrations over President Bush's visit -- as much as 50,000 to 60,000 people," Sir John Stevens, the Scotland Yard chief, told the Police Complaints Authority.
But more serious and substantial demonstrations are expected this year, with protests against the Olympics being planned yesterday when a coalition of groups opposed to the Games met in London for the first time.
In conclusion, this clinical trial provides the demonstration of a substantial clinical activity of the association of cetuximab plus weekly irinotecan as third-line treatment in oxaliplatin- and irinotecan-pretreated colorectal cancer patients.
The role of γδ T cells in tularemia has been poorly studied so far, including mainly demonstrations of a substantial increase in the proportion of circulating γδ T cells in human tularemia patients [43] [44].
The two pathways to programmatic success, neither of which are likely in an austere financial environment, are a lucky flight as a 'piggyback' mission or technology demonstration, or with a substantial and unprecedented investment to launch a scientific (e.g. seismic) network mission with a large number of vehicles such that a number of terrain-induced failures can be tolerated.
Dalton got his chance in May 2009 when his submarine, HMS Victorious, underwent what is known as a Daso, a Demonstration and Shakedown Operation, after a substantial refit.
