A hrs1.FA6 strain, which harbors all the nonphosphorylatable substitutions but lacks the T16A stabilizing mutation, does not show a substantial sporulation deficiency in the mad2Δ background, indicating that Hrs1 interferes with MI spindle formation only when it escapes both inhibitory mechanisms, namely proteasome-dependent degradation and phosphorylation.
Defining a gold standard for all species, considering the apparent substantial deficiency in each PPI database, however, appears inappropriate, even assuming that almost all yeast two-hybrid data is correct [ 31].
The other paper described how SNOMED could support a quality audit which has discovered substantial deficiencies in performance of a surgical pathology laboratory [ 7].
Bank of America's "contention that the severity of [Merrill's] losses only came to light in recent days is problematic and implies substantial deficiencies in the due diligence," a Fed memo is quoted in the suit as saying.
However, he also notes that such people compromised themselves, and a society consisting mostly of other-directed individuals faces substantial deficiencies in leadership and human potential.
Existing GPS navigational systems are used extensively but have substantial deficiencies.
Our study also highlights many of the systemic issues related to out-of-hospital PEC in Yerevan as perceived by providers, along with substantial deficiencies in pediatric EMS services.
Indeed, substantial deficiencies in medical education on smoking-related issues have been described [ 11– 15].
Overall, our analysis identifies substantial deficiencies in the treatment of genetics in state standards across the United States.
The NRC (2008) found "substantial deficiencies" in the current approaches to the treatment of uncertainty and variability in quantitative risk assessment of both cancer and noncancer outcomes.
While some children may have required intensive high-cost care, the majority of caretakers revealed substantial deficiencies in provision of basic health care.
