The phrase "a substantial defect" is correct and usable in written English.
It can be used in contexts where you are discussing a significant flaw or issue in a product, system, or process.
Example: "The inspection revealed a substantial defect in the manufacturing process that needs to be addressed immediately."
Alternatives: "a significant flaw" or "a major issue".
New York's "lemon" law entitles consumers to a replacement car if a new car still has a substantial defect after four repairs.
In vitro, the C. neoformans met3 mutant had a substantial defect in melanin formation, significantly reduced growth rate, and greatly increased thermotolerance.
The spt16-m allele contains two amino acids substitution (K692AR693A) in its tandem pleckstrin homology (PH) domain and displays a subtle defect in transcription initiation but a substantial defect in DNA replication-coupled nucleosome assembly (Yang et al., 2016).
On the other hand, Notch1 receptors lacking the S1 loop exhibit a substantial defect in transport to the cell surface, with steady state cell-surface levels reduced by 5 10-fold, even though there are comparable levels of overall expression.
Given our failure to find a substantial defect in ErbB2 transcription or protein degradation rates, we suspected this higher molecular weight form may represent ubiquitinated ErbB2 that accumulates upon POH1 knockdown and may be less easily detectable by western blotting due to its heterologous molecular weight.
We looked at ribosome biogenesis, and were inspired when we noticed that there is a substantial defect in rRNA transcription.
Surprisingly, our own more detailed analyses did not reveal any substantial defect of osteoclast-specific gene expression in PLCγ2−/− cultures, and the expression of NFATc1 was not at all affected by the PLCγ2 mutation (Fig. 4b).
However, various features of the disorganized cortex indicated a more substantial defect of cortical layering (Caviness and Rakic 1978; Rakic and Caviness 1995).
We next monitored the accumulation of RAD51 foci following irradiation and found a more substantial defect in INO80-depleted cells (Fig 2B).
Proteasomes from this strain grow at the permissive temperature were proteolytically active but migrated faster than 26S holoenzymes suggesting a more substantial defect than merely loss of labile Rpn12.
MHs are considered complicated by the authors when one of the following apply: (a) a history of MH for 6 months or more; (b) after primary or even secondary retinal surgery, for example, when short-term endotamponades, such as SF6 or C3F8, were unsuccessful; or (c) whenever a larger central substantial defect was appreciated when the indication for the operation was established.
