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Our results with VEGF are in accordance with the hypothesis that, when monitoring the efficacy of cytotoxic therapy, a substantial decrease in the levels of tumor marker often correlates with response to therapy whereas an increase or an insufficient decrease are generally associated with no response or disease progression.
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"We are confident that such efforts will result in a substantial decrease in the level of unrest," the memo says, "but we must also stress that confidence-building measures cannot be held hostage to an unattainable and unnecessary standard.
Short-term results in 12 patients have demonstrated satisfactory outcomes as a salvage procedure with improved function and a substantial decrease in the level of pain.
Our results reveal a substantial decrease in the level of all ErbB family members analyzed after treatment with B-10.
As demonstrated in Figure 3C, we observed a substantial decrease in the level of nascent transcription for TAF7, PTB, and SELENBP1 genes in Drosha-knocked-down cells.
The A673T mutation causes a substantial decrease in the level of the soluble APP fragment processed by β-secretase (sAPPβ) [ 9, 18].
Comparison of the occurrence of solar energetic particle events, and the estimated HMF, shows that a substantial decrease in the size and frequency of occurrence of GLE (ground level enhancements) after 1958 coincides with a substantial increase in the HMF.
"This has, in turn, affected consumer spending and business growth, resulting in a substantial decrease in the UK's GDP.
Our results show a substantial decrease in the mortality rate.
While the MEK1 or MEK2 knock-down alone did not show a substantial decrease in phospho ERK levels, the double knock-down showed a significant decrease in phopsho ERK levels (Figure 3B).
Similarly, treatment with a TRiC inhibitor (TRiCi), which has been shown to inhibit archaeal TCP1 activity in vitro26, led to a substantial decrease in CSA levels while not affecting TCP1 levels itself (Fig. 3d).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com