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Up to the mid-1980s, a substantial decrease in the incidence of human brucellosis was observed in Germany.
There has been a substantial decrease in the incidence of THR in patients with rheumatoid arthritis after 2001, due to more effective pharmacological treatment (Hekmat et al. 2011).
We report a substantial decrease in the incidence of CNS metastases with increasing age in elderly patients with HER2-positive MBC.
After the introduction of the Haemophilus influenzae type b (Hib) conjugate vaccine, there was a substantial decrease in the incidence of Hib meningitis, while the incidences of pneumococcal and meningococcal meningitis remained stable [ 6].
The institution of a TB-screening program for the homeless population in congregate settings in Denver in 1995 was associated with a substantial decrease in the incidence of active TB in this high-risk population.
After implementation of an amendment emphasising the use of loperamide in case of diarrhoea (after inclusion of the first 35 patients), a substantial decrease in the incidence of severe diarrhoea appeared: the incidence of grade 4 diarrhoea in the 35 mg m−2 group dropped from 26 to 8%.
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Overall, we observe a substantial decrease in the two weeks incidence rate, nowhere did we find rates exceeding 50 or even 60% as documented in a large study conducted a decade ago (3, 4).
In developed nations, a substantial decrease in the invasive pneumococcal disease (IPD) incidence rate has been achieved through the introduction of the 7-valent pneumococcal conjugated vaccine (PCV-7) into pediatric immunization programs.
"This has, in turn, affected consumer spending and business growth, resulting in a substantial decrease in the UK's GDP.
Our results show a substantial decrease in the mortality rate.
In that case, we observed a substantial decrease in relative incidence for adults due to the assumed decrease in work contacts.
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