The phrase "a substantial decrease in expression of" is correct and usable in written English.
It can be used in contexts discussing changes in levels of expression, often in scientific or academic writing related to biology or genetics.
Example: "The study revealed a substantial decrease in expression of the target gene after treatment with the drug."
Alternatives: "a significant reduction in expression of" or "a marked decline in expression of".
Interestingly, we observed no substantial decrease in expression of the Sulf1 message in RNA derived from the testis (Fig. 1C).
Transfection of the cells with siRNA for GM2/GD2 synthase resulted in substantial decrease in expression of this enzyme on the mRNA and protein levels.
Nevertheless, as with MdfA-PhoA a substantial decrease in the expression of MdfA379-PhoA was observed only under FtsY-depletion conditions compared with cells depleted of Ffh (Figure 1, compare G with H).
The growth defect was associated with a substantial decrease in the expression of targeted genes (Fig. 5).
Consistent with previous observation [10], when Aurora-A was co-expressed with different amounts of Cdh1 in HEK293T cells, the increase in the protein level of Cdh1 was accompanied by a substantial decrease in the expression levels of Aurora-A.
Consistently, upon knockdown of either TCF4, c-Myc or p68 in mouse 4T1 cells using respective siRNAs, we have found a substantial decrease in the expression levels of p68.
A substantial decrease in claspin expression indicated loss of checkpoint-mediated ATR control of the cell cycle following DNA damage.
A substantial decrease in PP2A expression and modest decrease in PP1 expression were observed in neuronal cultures treated with QA.
There was no difference in Bcl-2 expression; however, there was a substantial decrease in TRAIL expression when mice were treated with both pmel and TRP-1 T cells (Fig 5B), implying the addition of tumor-specific CD4+ T cells increases CD8+ T-cell persistence by reducing exhaustion by the PD-1 pathway and decreasing TRAIL-induced apoptosis.
In contrast, treatment with ATO in the presence or absence of panobinostat resulted in a substantial decrease in PML expression.
