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Secondly, SOCS2 knockdown results in a substantial decrease in cell proliferation and clonogenicity in AR-negative and -positive cell lines.
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In addition, under the latter condition there was a substantial decrease in cell viability (Fig. 3C,D).
These defects result from significant decreases in cell proliferation and aberrant cell death in both the pharyngeal endoderm and splanchnic mesoderm.
Furthermore, there was a substantial decrease in B cell development.
These changes are accompanied by a reduction in cell proliferation and a substantial decrease in tumour burden in DLBCL xenografts.
However, MU treatment resulted in a substantial decrease in the diameter of cell-associated matrices.
No substantial decrease in cell number over time was detected.
In contrast, 100 μg/ml of AC extract showed no substantial decrease in cell viability.
Interestingly, a substantial decrease in miR-122 activity was noted in cells receiving gp63-containing liposomes.
A substantial decrease in TrxR activity was observed already after 4 h in the H1299-His175 cells.
"It is a substantial decrease in our bonds," she said.
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