The phrase "a substantial decrease after" is correct and usable in written English.
It can be used to describe a significant reduction that occurs following a specific event or time period.
Example: "There was a substantial decrease after the new policy was implemented, leading to improved efficiency."
Alternatives: "a significant drop following" or "a considerable decline after".
More recently, it was observed that retinoblastomas containing cavitary spaces, indicative of well-differentiated retinoma areas, did not show a substantial decrease in size after chemotherapy (Mashayekhi et al., 2005).
Several studies show a substantial decrease in antibiotic prescribing after the introduction of RADT [ 7, 8].
In spite of the limitations mainly due to its retrospective and multicenter design, our study shows a substantial decrease in drug resistance after stratification for antiretroviral class in use at failure.
Fluorescence microscopy images of films acquired during this experiment revealed a substantial decrease in total fluorescence after 240 days, but that the peptide was not completely released over this time period, consistent with the release profile shown in Figure 5 A (a representative image of a loaded film prior to incubation is shown for comparison in Figure 5 B).
Immunofluorescent staining showed a substantial decrease in overall MITF staining after 24 h of incubation with [6]-shogaol; this staining was absent in the nucleus and showed a diffuse cytosolic distribution after [6]-shogaol treatment.
After a substantial decrease of the stillbirth rate, by two-thirds from 1950 to 1975, related to prevention and treatment of infection and improved obstetric care, this decline has slowed or halted in high-income countries during the last few decades [ 4].
Although endoscopic staging failed to significantly improve (p > 0.05) in a placebo-controlled trial, a separate RCT observed a substantial decrease in computed tomography scores after montelukast treatment (p < 0.05) that was equivalent to the improvement shown after INCS treatment (p > 0.05).
While one prior study found a substantial decrease in immediate neonatal costs after specialised antenatal care for twin pregnancy was introduced, neither maternal cost of care nor implementation costs were assessed [ 7], and we are not aware of any prior studies where a full economic evaluation of a specialised multiple pregnancy clinic has been performed.
As a result of multivariate logistic regression, a substantial decrease in odds ratio was observed after adjusting for GHQ-12 total score, which also suggested a mediating effect of poor mental health.
The fact that blockade of spinal NMDA receptors produced a substantial decrease in nNOS only 6 hours after intrathecal injection of the NMDA antagonists reveals an active and fast turnover of this constitutive enzyme in dorsal horn cells.
