The phrase "a substantial concern of" is correct and usable in written English.
It can be used when discussing an important issue or matter that is relevant to a particular subject or group.
Example: "Environmental sustainability is a substantial concern of our organization as we strive to reduce our carbon footprint."
Alternatives: "a significant issue for" or "a major worry of".
Services have been established, but there is now a substantial concern that significant numbers of services are failing to attain the standards set for multi-factorial programmes by NICE.
Examination of the raw data (not shown) shows nearly identical means scores for the groups, suggesting that the lower ICC values were not a substantial concern, and reflected a lack of precision around the estimates in this sample.
Will the substantial concerns of Günter Grass, W. G. Sebald and Bernard Schlink -- all deeply influenced by the Holocaust, Germany's societal wounds and the specter of war -- end with their generation?
The substantial concerns of the 3 reviewers are: Reviewer 1: 1) Is the generated sequence data accessible through a public repository such as GEO? Are database accession numbers provided somewhere in the manuscript.
A simultaneous balance of development of nanotechnology-based therapeutic approach and safety of human healthcare is a matter of substantial concern as the field of nanotechnology is promising yet.
Instead, he used the occasion to downplay the impact of the Greek crisis on the U.S. economy, calling the threat of a Greek default and eurozone departure an "issue of substantial concern," but one that is "primarily of concern to Europe".
There can be no question that the public debates at the sessions of the city council regarding Bresler's negotiations with the city were a subject of substantial concern to all who lived in the community.
Background: The quality of medication use in older adults is a recurring problem of substantial concern.
Of substantial concern is the increasing problem of antibiotic resistance – a problem that ICUs both contribute to as well as suffer from [ 4].
