The phrase "a substantial concern for" is correct and usable in written English.
It can be used when discussing an issue or topic that is significantly troubling or important to someone or a group.
Example: "The rising levels of pollution present a substantial concern for public health officials."
Alternatives: "a significant worry for" or "a major issue for".
BACKGROUND: Bacterial meningitis represents a substantial concern for individuals with cochlear implants (CIs).
During the conference, President Rouhani addressed Iran's controversial and a decades-long nuclear program which has been a substantial concern for the International Atomic Energy Agency IAEAA), the international community, the United States, and its allies.
"It was just a matter of time". How the public will react to the disruption brought about by slower growth is a substantial concern for the Chinese government, analysts said.
"Duke's recent environmental problems suggest serious lapses in oversight as well as failures in risk management by the board of directors and are a substantial concern for investors," said Bill Dempsey, senior vice president of the Nathan Cummings Foundation, a social justice agency based in New York.
The costs and inconveniences associated with such waste are a substantial concern for some patients.
The perceived associations between dento-facial attractiveness and social traits, such as personality and social status, make dental appearance a substantial concern for many people [ 16].
These findings indicate that stigmatisation is an issue of substantial concern for people with T2DM, and has harmful consequences.
Since we had 183 responders and 18 predictors, the ratio of the total number of responding participants to the number of potential predictors was greater than 10 [ 40, 41], so all variables were included in our multivariable model without substantial concern for overfitting.
Pre-exposure prophylaxis with orally administered antiretroviral drugs may prove effective, but there are substantial concerns for toxicities associated with long-term exposure and the risk for selecting resistant viral variants.
The tendency of powder mixtures to demix due to segregation is a substantial technical concern for manufacturing of pharmaceutical solid dosage forms.
