The phrase "a substantial clinical problem" is correct and usable in written English.
It can be used when discussing significant issues or challenges in the field of healthcare or medicine.
Example: "The rise of antibiotic resistance has become a substantial clinical problem that requires immediate attention from healthcare professionals."
Alternatives: "a significant clinical issue" or "a major clinical challenge".
Peripheral nerve injuries represent a substantial clinical problem with insufficient or unsatisfactory treatment options.
However, many ErbB2-positive cancers exhibit intrinsic resistance, and the widespread development of acquired resistance to ErbB-targeted agents remains a substantial clinical problem.
iDILI represents a substantial clinical problem as it can arise from drugs that are very commonly prescribed and thus represents a widespread issue.
Others have recognized acute and chronic pain in this patient population as a substantial clinical problem [ 29- 31], while others have not [ 7, 8].
Youth onset of type 2 diabetes continues to increase worldwide (1), and pregnancy in women with type 2 diabetes is a substantial clinical problem (2).
However, because HA rotavirus infection remains a substantial clinical problem ≈20 years after publication of a seminal study on the subject (22 ), even stringent infection control precautions are likely to be insufficient to greatly reduce the problem.
This review will summarize the most recent research designed to address this substantial clinical problem and provide clinicians with relevant background for understanding some of the potential molecular mechanisms for resistance to targeted therapies in the treatment of patients with breast cancer.
Indeed, it has been reported that breast carcinoma in younger patients comprises substantial clinical problems.
Despite these benefits, a substantial proportion of patients will develop de novo or acquired resistance to hormone therapy and this presents a significant clinical problem.
