The high prevalence of antibodies among adult birds also suggests that substantial circulation of the virus may have occurred during the previous season or seasons.
And more of the newspapers involved have substantial circulations, like The Portland Press Herald, in Maine, which circulates 77,000 copies daily and 123,000 on Sundays.
During the run-in to September's referendum the Herald registered a substantial hike in circulation.
The Dallas Morning News, the flagship of the Belo Corporation, moved ahead of The San Francisco Chronicle into the No. 11 spot by reporting a substantial 2.3percentt daily circulation gain, to 522,000 from 510,000.
Furthermore, even during peak periods of influenza circulation, a substantial number of cases of febrile respiratory illness may have non-influenza etiologies.
The basic principle of this approach is that, after entering the systemic circulation, a substantial proportion of nicotine can be bound by antibodies.
Given that blood draining the intestine passes through the liver before further circulation, it is likely that local responses in the liver to intestinal stimuli are a substantial source of circulating cytokines [50], [51].
Inlet designs can induce non-uniform liquid flow across the separator's cross section with a substantial zone of re-circulation.
