The phrase "a substantial change of" is correct and usable in written English.
It can be used when discussing significant alterations or transformations in various contexts, such as policies, plans, or conditions.
Example: "The company announced a substantial change of its marketing strategy to better reach younger audiences."
Alternatives: "a significant shift in" or "a major alteration of".
Mr. Clinton said that after the announcement late Wednesday that no agreement had been reached, there had been a substantial change of mind.
But she should recognize that such a course would mean a substantial change of strategy, taking EDC away from those things it does best.
For an oil-and-gas megalopolis that rose out of the swampy bayous, all of these sustainability initiatives amount to, at a minimum, a substantial change of emphasis.
In 1987, having achieved considerable prominence in Europe, he took on a substantial change of environment, accepting a professorship at the University of California, San Diego; two years ago he moved to Stanford.
I think it would be totally wrong to cave into the Mark Thompson/Channel 4/Guardian line that this represents a substantial change of control given that we all know Sky is controlled by News Corp now anyway..
Although he was speaking generally rather than singling out the UK, Carney's comments will nonetheless be seen as evidence that he is preparing a substantial change of direction when he takes up his new post.
It seems like a small change, but it was a substantial change to the meaning of our message.
Payments on account of business interests are deemed property, and are, therefore, fixed unlike support payments, which are generally modifiable upon a showing of a substantial change in circumstances of either the payor or the payee.
That the GOP has now taken control of the Senate marks a substantial change in terms of leadership but not a particularly consequential one in terms of legislation.
For me to be eligible, there has to be a substantial "change in conditions" of my work.
In addition, a substantial change in the focus of early childhood policy has accompanied the change of government.
