The phrase "a substantial change as" is not correct and may be incomplete in written English.
It could be used in contexts where you are comparing or explaining a significant change in relation to something else, but it needs additional context to be clear.
Example: "The new policy represents a substantial change as it alters the way we approach customer service."
Alternatives: "a significant change in" or "a major shift regarding".
But since that scene at the university unfolded in May, the move toward political reform seems to have stalled, and with it the expectation that Egypt will experience any substantial change as long as Hosni Mubarak, the 75-year-old president who has governed for 22 years, remains in office.
This scenario has the potential to drive substantial change as long as the environmental NGOs involved fully grasp the conservation science at the local level.
Mr. Monti's two-week-old government stands hard-pressed to restore international confidence in the ability of its political class to make substantial changes, as well as in the merits of its industry.
Quantitative change remains describable in terms of assimilation (or discrimination) of entities, but these processes will be substantial changes as far as the assimilated or dissimilated and segregated entities in the process are concerned (see esp.
"You are going to see a substantial change even as the case makes its way through the courts".
"You are going to see a substantial change even as the case makes its way through the courts," Obama told the group.
"We are unaware of any other nation that has enacted such a substantial change in gun laws as has been implemented in Australia," the authors said in the study.
It can result in a substantial change in sound, as it did with the Tokyo String Quartet, or even dissolution, as it did with the Cleveland Quartet.
Co-culture with WJMSCs results in a substantial change in the kinetics (expression was seen as early as 12 hr of activation) and expression levels of the negative co-stimulatory ligand, CTLA4 on PBMCs (Figure 4B {ii}).
This represents a substantial change in the picture as our understanding was refined.
