Sentence examples for a substantial challenge facing from inspiring English sources

There is a substantial challenge facing views such as Reid's.

There are substantial challenges facing humanity in the water and related sectors and purposeful integration of the disciplines, connected sectors and interest groups is now perceived as essential to address them.

Hackett faces a substantial challenge.

Since the outcome measures of lung impairment have considerable test-to-test variability, potential new therapies face a substantial challenge.

9 We thus are faced with a substantial challenge.

Aspects of complexes involving ankyrin repeats, including featureless putative binding face surfaces and large binding interfaces, can present a substantial challenge to the development of small molecule inhibitors.

Reestablishing fiscal and financial sustainability, in the face of low or negative growth and high interest rates, is a substantial challenge, and will take time.

The (apparently substantial) challenge now facing UK hospitals, is how will they meet their patients' demand for health education?

The fundamental choice is whether its trajectory will remain marked by inertia... and by ineffective policies that have produced the substantial development challenges facing the region; or whether prospects for an Arab renaissance, anchored in human development, will be actively pursued".

With a staff of 25,000 and 1,000 buildings, the challenge facing Manchester city council is substantial.

KPMG said a range of challenges facing the airline raised "substantial doubt about its ability to continue as a going concern," the auditors' report said.