The phrase "a substantial challenge due" is correct and usable in written English.
It can be used when discussing a significant difficulty or obstacle that is expected to occur or has been caused by a specific factor.
Example: "The team is facing a substantial challenge due to the unexpected changes in project requirements."
Alternatives: "a significant challenge caused by" or "a major challenge resulting from".
However, the efficient incorporation of Uaas in response to the amber stop codon in mammalian cells remains a substantial challenge due to the competition from release factor 1 RF1).
Programmability remains a substantial challenge due to the different types of NP architectures, the evolution of networking standards and applications, and the unavailability of a unified and widely accepted set of software development and performance prediction tools.
However, AD detection, particularly in the early stages, remains a substantial challenge due to the lack of specific biomarkers.
Accurate projection of known carbohydrate catabolic pathways across diverse bacteria with complete genomes constitutes a substantial challenge due to frequent variations in components of these pathways.
Furthermore, implementing evidence based practice in residential care setting represents a substantial challenge due to the lack of good quality evidence.
However, previous efforts to acquire the high ORR activity by non-precious material and carbon composites faced substantial challenges due to a few active sites during electrochemical reactions.
ClinicalTrials.gov NCT00675389 The provision of antiretroviral therapy (ART) in low-resource settings entails substantial challenges due to human resource limitations [1].
Untangling S. japonicum physiology can have important ramifications for efforts to control schistosmiasis, which remains a substantial challenge in endemic areas due to the difficulty of eradicating the snail intermediate hosts.
Currently, solid-state fermentations with bacteria are generally avoided due to irreversible adsorption of cells to solid materials, thereby presenting a substantial challenge with regard to cell growth characterization.
