The phrase "a substantial cell" is correct and usable in written English.
It can be used in contexts related to biology, technology, or any field where the size or importance of a cell is being discussed.
Example: "In our study, we observed a substantial cell that exhibited unique characteristics compared to the others."
Alternatives: "a significant cell" or "a considerable cell".
In line with the predictions, UMPS knockout caused a substantial cell number reduction in HK-2 cells compared to knockouts of GCLC, GSS, and RRM2B, thereby indicating a substantially superior toxicity in normal kidney epithelial cells.
Here, we show that the chick cranial NCCs delamination is the result of two events: a substantial cell mobilization and an epithelium to mesenchyme transition (EMT).
LS180 adenocarcinoma cells expressing WT cofilin (Fig. 2d f) or S3A cofilin (Fig. 2g i) were characterized by the colocalization of F-actin and cofilin (Fig. 2f, i long arrows) that was accompanied by a substantial cell spreading.
It is quite possible that the continuously ongoing formation of respiratory chain-deficient neurons in the ageing human brain may lead to a substantial cell loss over time (22).
In conclusion, a substantial cell increase, combined with a high proportion of stem/progenitor cells, was seen throughout the length of the Achilles tendon after a mid-tendon rupture.
The impairment of β-catenin signaling in Dox-treated HuH6sh cells1 cells was associated with a substantial cell growth defect when cells were seeded at very low density (Additional file 2: Figure S1-A), whereas cell growth was not significantly affected when cells were seeded at medium density (Additional file 2: Figure S1-B).
Two days following cell delivery, GFP ELISA-based assay revealed a substantial cell-retention efficiency (10.48 ± 2.86%, n = 7) in mouse lungs preinjured with 2% polidocanol.
Previous work demonstrated a 0% survival rate in mice immunized with B. pseudomallei-pulsed dendritic cells though the immunization generated a substantial cell-mediated immune response [16].
The resulting autophagosome score distribution at 4 h (Fig. 3B, dash line) showed a single peak at 0.02, indicating that on average about 2% of total GFP-LC3 intensity resided in puncta, but there was a substantial cell-to-cell variability.
These results were obtained following direct stimulation of the molecule under "in vitro" conditions closely resembling a physiological setting and without substantial cell manipulations.
Additionally, in this case we observed a substantial mean cell number reduction for the group of siRNAs targeting genes predicted to be essential in silico compared to those predicted to be nonessential (p < 0.001, Fig. 3C).
