The phrase "a substantial burden to" is correct and usable in written English.
It can be used when discussing an obligation, challenge, or difficulty that significantly impacts someone or something.
Example: "The new regulations impose a substantial burden to small businesses, making it harder for them to operate efficiently."
Alternatives: "a significant strain on" or "a considerable challenge for".
Tendon injuries and defects present a substantial burden to global healthcare economies.
This broad clinical spectrum, together with the high incidence of these disease manifestations and magnitude of the diverse populations at risk, presents a high unmet medical need and a substantial burden to the healthcare system.
Such laws could pose a substantial burden to researchers at institutions like Harvard and the University of Kansas who are convinced that salvia's active compound, Salvinorin A, holds great promise and will aid in the development of new lines of pain and psychiatric medications.
Such laws could pose a substantial burden to researchers at universities like Harvard and the University of Kansas who are convinced that salvia's active compound, Salvinorin A, will aid in the development of new lines of pain and psychiatric medications, and holds great promise.
CONCLUSION: Anaemia in patients undergoing chemotherapy presents a substantial burden to employers and payers.
Gunshot injuries due to assaults accounted for 74% of total costs.Gunshot injury costs represent a substantial burden to the medical care system.
However, former La Cañada Unified School Board President Scott Tracy told the committee that Glendale's remaining taxpayers would pay only $1.10 more per $100,000 assessed value a year, amounting to "no substantial burden to taxpayers," he said.
Judge Jackson said she did not have to address whether the act's strict test should be applied in this case to a company because the contraception coverage requirement does not rise to the level of a "substantial" burden needed to trigger the law.
A comprehensive decision-model based on analysis of a Canadian population-based Canadian administrative data source suggested that substantial costs per infant are observed in early and moderate preterm infants, but when scaled to the national level, late preterm infants contribute a substantial burden due to the relatively larger population size.
While the proportion of bacteriuric subjects who develop symptomatic infection is low, the high frequency of use of indwelling urinary catheters means there is a substantial burden attributable to these infections.
Surgical complications represent a substantial burden of harm to patients and in the United States alone are estimated to cost $25b annually.
