The phrase "a substantial and systematic" is correct and usable in written English.
It can be used to describe something that is both significant in size or importance and organized in a methodical way.
Example: "The research revealed a substantial and systematic approach to addressing climate change."
Alternatives: "a significant and organized" or "a considerable and methodical".
The Court likewise rejected the test for general jurisdiction proffered by the plaintiffs, under which general jurisdiction might be predicated upon a finding that the corporate defendant engages in a "substantial, continuous, and systematic course of business" in the forum state.
Proteomics is rapidly evolving into a high-throughput technology, in which substantial and systematic studies are conducted on samples from a wide range of physiological, developmental, or pathological conditions.
The last 15 years of research has conclusively shown that the brain undergoes "substantial and systematic" changes between puberty and the early twenties.
The assessment of wood properties is further complicated by substantial and systematic variation within trees such as early-latewood and juvenile-mature wood transitions (Zobel and Sprague 1998).
Technical noise due to variable quality of measurements can be substantial and systematic differences in the analytical methods including array platforms and data normalisation can make comparisons across data sets challenging.
A substantial and satisfying volume.
However, and importantly, we also showed that Chao's estimator can have a substantial bias (systematic error) when the Poisson assumption is violated.
There are a substantial number of systematic reviews and economic evaluations that examine the effectiveness and cost effectiveness of enhanced recovery programmes.
Hence, although different instruments and sequences were used, methods were fairly similar in 1989 and 2004, making a substantial systematic bias in results in 2004 vs. 1989 unlikely.
