The phrase "a substantial and persistent" is correct and usable in written English.
It can be used to describe something that is significant in size or degree and continues over a long period of time.
Example: "The study revealed a substantial and persistent increase in temperature over the last century."
Alternatives: "a significant and ongoing" or "a considerable and enduring".
Earlier research has established a substantial and persistent effect of displacement on labour market success.
As may be seen in the figure, there is a substantial and persistent gap between the annual hours of women from high and low activity rate countries: an unweighted average of 136 h across YSM categories.
At any rate, given the existence of a substantial and persistent wage penalty of being overeducated (discussed in Section 5), this result implies that overeducation is an important aspect of the gender wage gap, which is absent from most of the literature on this question.17.17
This last assumption explains why in the control peptide treatment group, unlike the 2 other treatment groups, the inverse fluctuations of the CD4+CD25+Foxp3+ and CD4+CD25− populations were absent since, as mentioned above, in this group only the level of CD8+CD28−Foxp3+ cells did not demonstrate a substantial and persistent rise.
Pulmonary alveolar proteinosis (PAP) is characterized by a substantial and persistent increase in surfactant pool size [ 1, 2].
Suffering from MDS causes a substantial and persistent functional decrement in a variety of areas, including the above mentioned, partially due to fatigue (81% of patients).
And of course I've never bought into the "wait until there's proof" approach to human-driven climate change, which — as I've stressed since 2007 — is more a challenge of risk management amid substantial and persistent uncertainty than a problem resolved by amassing scientific proof.
However, purely hypothetical concerns about the quality of data should not be used as an excuse to dismiss substantial and persistent differences in survival without quantitative examination.
However, a number of factors have profound impact on the composition of the microbiota and more substantial and persistent changes in the microbiota, a state also termed dysbiosis, are associated with various diseases [ 2, 38].
Formation of a synapse between neutrophils and platelets, a requirement for effective phagocytosis, is magnified under inflammatory conditions, where platelets undergo substantial and persistent activation [ 42].
Still, the talk is a good reminder that the basic science pointing to substantial human-driven climate change is clear, even as substantial and persistent uncertainty still obscures the timing and extent of the worst impacts.
