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In contrast, when A02 cells were exposed to both CTL and ABT-737, there was a substantial amplification of target-cell killing.
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This localization is indicative of substantial amplification in which a shallow external gradient is amplified to produce a steep internal gradient of certain proteins.
Using this approach, they could attain substantial amplification as each nanoparticle probe carried with it a large number of oligonucleotides per protein binding event.
It is found that the presence of HD-core region leads to decrease in amplitude of the propagating GW modes and the presence of disbond leads to substantial amplification of the primary anti-symmetric mode.
Thus, substantial amplification required some degree of cooperativity in the positive feedback loop [22].
Furthermore, the dramatic polarization of Ste20 and Spa2 argues for the presence of mechanisms capable of producing substantial amplification of the external spatial gradient.
For example, as many as 50% of patients with castrate-resistant metastatic prostate cancer have circulating cancer cells that have substantial amplification of the AR locus, which has been interpreted to predict that, in such patients, androgen signaling continues to play an important growth stimulatory role [45].
Immunoprecipitation with control rabbit IgG did not show substantial amplification of the expected PCR products (Fig. 4B, middle panel).
However genotyping for pncA requires substantial amplification and sequencing across the entire 558 base pair gene [ 28].
The initial steeply rising part of the curve reflects substantial amplification of low-contrast stimuli, permitting M-pathway neurons to respond robustly even at low contrasts.
For the latter two categories, substantial amplification involving either of the correlated variables is not expected, at least in the same sense as the term applies to nonincluded covariates.
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