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The phrase "a substantial amount of which" is grammatically correct and can be used in written English
It is commonly used to introduce additional information about a specific amount or quantity that has been mentioned in the sentence. Example: The company has invested a substantial amount of money in its new marketing campaign, a substantial amount of which will be used for social media advertising.
Exact(2)
Last month, New York agreed to settle a subsequent lawsuit he filed with the city for $4 million ― a "substantial" amount of which he is going to donate to help train public defenders. .
Firstly, the P. pacificus genome contains 23,500 predicted protein-coding genes, a substantial amount of which does not show sequence similarities to other metazoan genes.
Similar(58)
Audio and video together require a substantial amount of bandwidth, which can sometimes cause that sort of "concert experience" not to buffer very smoothly.
The RFL stepped in, offered my club a substantial amount of money, which I accepted and we moved the fixture as agreed – it helped the big club".
"Her attorney threatened legal action and negative publicity unless we paid her a substantial amount of money, which we refused to pay," he said.
It can be observed that the RD aluminium has a substantial amount of Al which of course proved to be highly useful for hydrogen generation.
Furthermore, they include a substantial amount of splitters, which is a significant drawback as they degrade the signal strength in the circuits.
Madejski told BBC Radio Berkshire he estimates that running the club has cost him around £50m and also revealed the new owners have "taken on a substantial amount of debt" which had built up at the club.
Re-stenosis occurs in a substantial amount of patients which have been treated with stent implantation [ 1].
Their bodies contain a substantial amount of water which has high thermal capacity making ant bodies an ideal medium for heat transfer.
Developing partnerships with willing districts and schools and acquiring parental consent for students requires a substantial amount of time, which is beyond the reach of most grants.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com