Site assignment of methionine oxidation using this workflow has two major drawbacks: (1) a substantial amount of sample is required to allow variant fractionation and subsequent peptide mapping (especially for low abundant variants) and (2) the procedure is time consuming, due to elongated sample preparation and LC-MS analysis.
However, a substantial amount of blood samples collected from a large number of individual animals is a prerequisite to ensure the diversity of the naïve library.
Affinity-based techniques require a substantial amount of starting sample, and their efficiency depends on the density of methylation marks within each specific fragment [ 43].
However, a substantial amount of this sample was not part of the Wave 1 parent interviews or measured for waist circumference and height at Wave 4. In addition, genome-wide association data is available on the sibling pair (SP) sample only.
In 1601, Hans Heinrich Nüschler signed a contract with his patron, Duke Friedrich of Württemberg in Stuttgart, to demonstrate his process for extracting a substantial amount of gold from a sample of silver.
A substantial amount of health survey research makes use of samples drawn from landline telephone numbers using random digit dialling (RDD) [ 5, 7].
In particular, the two factors that we found significant determinants of the precise localization of CO events the avoidance of exons and the enrichment of MM2 do not appear to apply to GC events (with the caveat that there is not a substantial amount of statistical power in our sample).
Although, we failed to capture a substantial amount of population diversity through the present sampling, it remains unlikely that sampling artefacts alone can account for similar intraspecific divergences found among freshwater and marine species.
To insert a substantial amount of recoverable viral particles into the sample collection system, a person trying to deceive the system would have to engineer and grow these viruses an act sufficiently close to actual bioterrorist use that it requires detection, whether the agent is a serious human pathogen or not.
Gypseous soil samples lose a substantial amount of their strength after a limited number of freeze thaw cycles.
