The phrase "a substantial amendment of" is correct and usable in written English.
It can be used when discussing significant changes or modifications to a document, policy, or agreement.
Example: "The committee proposed a substantial amendment of the original contract to better reflect the current needs of the project."
Alternatives: "a significant revision of" or "a major modification of".
Trial registration Current Controlled Trials ISRCTN46035546 We initially applied for a substantial amendment on the 5th of September 2011 to change the study design from individually randomised to cluster randomisation of patients by physiotherapists.
The sample size was extended to 120 patients with a substantial amendment to take into account a larger cohort of patients to report toxicities and survival outcome influenced by HPV status.
Based on the IoT Communication Reference Model, the poster proposes a substantial amendment to its layers through adding an extra layer called "Security Layer".
The original RCT needs assessment was approved in May 2008 by Warwickshire Research Ethics Committee (REC Ref: 08/H1211/57) with a substantial amendment for the RCT using the Zelen design in March 2010.
(See § 91.505). The citizen participation plan must include, among the criteria for a substantial amendment, changes in the use of CDBG funds from one eligible activity to another.
4 To obtain local R&D approval a named principal investigator and site need to be submitted to ethics through the Integrated Research Application System IRASS) either as part of the original trial application or as a substantial amendment afterwards.
While processing it as a substantial amendment can be a little onerous, approval letters are usually issued within a matter of days.
The interviews for this study were approved in a substantial amendment in May 2011 (REC Ref: 08/H1211/167).
The study had approval from the UK Multicentre Research Ethics Committee and the Oxfordshire Regional Ethical Committee A (07/Q1604/28) with a substantial amendment (1) approved on 30 April 2010.
