The phrase "a substantial alteration of" is correct and usable in written English.
It can be used when discussing significant changes or modifications to something, such as a document, plan, or system.
Example: "The committee proposed a substantial alteration of the original policy to better address the needs of the community."
Alternatives: "a significant change to" or "a major modification of".
Both PSF and TOF reconstruction resulted in a substantial alteration of SUVmax in CRLM.
Therefore, we hypothesized that AA infusion for nephroprotection in ERT might lead not only to hyperkalemia but also to a substantial alteration of the acid base status namely metabolic acidosis.
At the same time the majority of ionotropic glutamatergic receptors differentially expressed were up-regulated in these brain regions in depressed suicides, reinforcing the idea of a substantial alteration of glutamatergic neurotransmission in this group.
To the best of our knowledge, our study demonstrates for the first time a substantial alteration of placental gene expression following in vitro manipulation techniques of the embryo (above 6% of the transcripts), with a significant excess of repressed genes in the complete transcriptome.
In [ 18- 20], optimization techniques are used to determine which reactions can be eliminated from the original model without a substantial alteration of the model behaviour.
Clinical studies have shown that destination therapy with ventricular assist devices improves patient survival compared to medical management, but at the cost of a substantial alteration in end-of-life trajectories.
We found that although Myog-deleted cultured satellite cells were able to fully differentiate into myotubes as efficiently as wild-type satellite cells, the absence of myogenin resulted in a substantial alteration in the expression of genes encoding proteins involved in cell signaling and cell fusion [9].
This blockage of drug efflux may be mediated by a substantial alteration in the fluidity of cell membranes induced by Cremophor, as shown by decreased fluorescence anisotropy of a membrane probe.
They often suffer of a substantial alteration due to an increasing atmospheric pollution.
However, a substantial alteration in the differentiation potential of ADSCs from both early and late passages (3rd and 14th, respectively) was found when the cells were switched to osteogenic differentiation conditions.
As a result of 1990s UK local government reform, York regained unitary status and saw a substantial alteration in its borders, taking in parts of Selby and Harrogate districts, and about half the population of the Ryedale district.
