Sentence examples for a substantial aggravation from inspiring English sources
Moreover, inactivation of PD-1 in an animal model for inherited demyelination in the peripheral nervous system implicating T-lymphocytes [13] leads to a substantial aggravation of the primarily genetically-caused neuropathy [14].
Dihydrokainate alone caused a substantial aggravation of the clinical EAE course thereby demonstrating the need for sufficient glial glutamate uptake during an autoimmune inflammatory challenge and indirectly confirming the role of glutamate excitotoxicity in EAE pathogenesis.
Aggravation can be assisted by amending the policies of Annex I countries, in consequence to allocate a substantial share of their procurement activities to Certified Emission Reductions from least developed countries.
We made a substantial bid.
A substantial irony enters here.
That is a substantial amount.
A substantial and satisfying volume.
This is a substantial upgrade".
This is a substantial grievance.
A Substantial Drink Problem.
