a substantial affinity

USAGE SUMMARY

The phrase "a substantial affinity" is correct and usable in written English.
It can be used to describe a strong connection or similarity between two entities, ideas, or individuals. Example: "The research revealed a substantial affinity between the two species, indicating they share a common ancestor."

✓ Grammatically correct

Science

News & Media

Human-verified examples from authoritative sources

Exact Expressions

6 human-written examples

Intrinsic fluorescence study reveals that the concerned gemini surfactants have a substantial affinity for PSA at a pH well above its isoelectric point.

Process Biochemistry

Fabp3 is expressed in mature neurons in the dentate gyrus (our unpublished results) and reported to have a substantial affinity to ARA [31].

Plosone

In 48 out of 100 RSC-DNA complexes only one extruding DNA end could be resolved, suggesting a substantial affinity for DNA ends.

Plosone

However, it retains a substantial affinity for HP that might result from the stabilization of the complex through the collaboration between the conserved BBXB motif in the core of the chemokine and the remaining positive charges in the yet highly cationic C-ter domain.

Plosone

These findings confirmed that etanercept has a substantial affinity for rabbit intra-articular TNF-α.

Acta Orthopaedica

The selection of the anti-Id scFv, performed by three rounds of panning of the synthetic ETH-2 scFv library on immobilised trastuzumab F ab′ 2 fragments (Ab1), resulted in a substantial affinity enrichment of the library on either trastuzumab or human IgG1 F ab′ 2 fragments (used as a control) as checked by ELISA using the recombinant polyclonal phage supernatants.

British Journal of Cancer

Human-verified similar examples from authoritative sources

Similar Expressions

53 human-written examples

Here, we engineered a tandem repeat construct (SRC2) showing substantial affinity for α2,6-sialylated N-glycans (in the order of 10−6 M in Kd), almost comparable to a natural α2-6Sia-specific lectin from Sambucus sieboldiana (SSA).

Biochemical and Biophysical Research Communications

These studies found that Diva does not show "substantial affinity" for any BH3-derived peptide, including Bak and Harakiri.

Plosone

Of all the human UGTs, only UGT1A10 was found to have substantial affinity to DA [ 140], but there is no UGT1A10 expression in the brain [ 140] that could be responsible for the DA-glucuronides found there [ 135].

Cell Communication and Signaling

For example, both rat and human proteins bound to sialylated sugars, but the former recognized a broad range of biantennary structures (e.g. ligands 143, 219, 255 and 199), whereas the latter recognized only one of these with substantial affinity: ligand 143.

European Journal of Immunology

Our finding that Puma does not bind Bcl-B with substantial affinity leaves only Bim to bind tightly to all six prosurvival proteins, hence making it the only universal apoptotic initiator among the BH3-only proteins and most potent prosurvival antagonist.

Cell Death and Disease

Expert writing Tips

Best practice

When using "a substantial affinity", ensure the context clearly indicates what the affinity is for. Providing specific details enhances clarity and avoids ambiguity. For instance, specify the molecules, ideas, or individuals involved.

Common error

Avoid using "a substantial affinity" when describing a weak or superficial connection. Overstating the intensity can mislead your audience and undermine the credibility of your statement.

Linguistic Context

The phrase "a substantial affinity" functions as a noun phrase, where "substantial" modifies the noun "affinity". As Ludwig AI confirms, it is used to describe a significant degree of likeness or connection. Examples show its use in scientific contexts to denote strong binding or attraction between molecules.

Expression frequency: Uncommon

Frequent in

Science

68%

News & Media

25%

Formal & Business

3%

Less common in

Encyclopedias

0%

Wiki

3%

Reference

0%

Ludwig's WRAP-UP

In summary, "a substantial affinity" is a phrase used to express a significant connection or similarity between entities, as confirmed by Ludwig AI. It is grammatically correct and most frequently found in scientific and news contexts. While "substantial" emphasizes the degree of affinity, related phrases like "a strong attraction" or "a considerable liking" offer nuanced alternatives. When using this phrase, ensure the context clearly identifies the entities and the nature of their affinity. While authoritative sources employ the phrase, it's crucial to avoid overstating the connection and ensure that it accurately reflects the relationship being described.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

a considerable liking

Replaces "affinity" with "liking", suggesting a preference or fondness rather than a deeper connection. Also replaces "substantial" with "considerable" but doesn't change the phrase meaning.

a significant inclination

Uses "inclination" instead of "affinity", implying a tendency or predisposition. Also replaces "substantial" with "significant" but doesn't change the phrase meaning.

a marked fondness

Substitutes "affinity" with "fondness", indicating a feeling of affection or warmth. Also replaces "substantial" with "marked" but doesn't change the phrase meaning.

a strong attraction

Replaces "affinity" with "attraction", emphasizing the pull or allure of something. Also replaces "substantial" with "strong" but doesn't change the phrase meaning.

a notable connection

Replaces "affinity" with "connection", focusing on the link or relationship between things. Also replaces "substantial" with "notable" but doesn't change the phrase meaning.

a considerable resemblance

Uses "resemblance" instead of "affinity", highlighting similarity in appearance or nature. Also replaces "substantial" with "considerable" but doesn't change the phrase meaning.

a significant relationship

Replaces "affinity" with "relationship", focusing on the bond or association between entities. Also replaces "substantial" with "significant" but doesn't change the phrase meaning.

a marked similarity

Substitutes "affinity" with "similarity", emphasizing the shared qualities or characteristics. Also replaces "substantial" with "marked" but doesn't change the phrase meaning.

a deep-seated connection

Replaces "substantial affinity" with "deep-seated connection", to imply strong and persistent affinity.

a profound liking

Replaces "substantial affinity" with "profound liking", to imply a liking beyond the superficial level.

FAQs

How can "a substantial affinity" be used in a sentence?

You can use "a substantial affinity" to describe a significant connection or similarity between two things. For instance: "The study revealed a substantial affinity between the two proteins."

What are some alternatives to "a substantial affinity"?

Some alternatives include "a considerable liking", "a significant inclination", or "a strong attraction". The best choice depends on the specific context.

Is it more appropriate to say "substantial affinity" or "strong affinity"?

Both "substantial affinity" and "strong affinity" are correct, but "substantial" emphasizes the degree or amount of the affinity, while "strong" emphasizes the intensity or power of the affinity. The choice depends on the nuance you wish to convey.

What does "a substantial affinity" imply about the relationship between two things?

Using "a substantial affinity" suggests that there is a noteworthy and significant connection or similarity between the two things being described. It implies more than just a superficial resemblance or casual link.