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The phrase "a substantial address" is correct and usable in written English.
It can be used when referring to a speech or presentation that is significant in content or length.
Example: "The keynote speaker delivered a substantial address that captivated the audience for over an hour."
Alternatives: "a significant speech" or "an important presentation."
Exact(2)
But he also gave a substantial address to Catholic educators, many of whom have been struggling with shortages of money, changing missions and conflicts over whether Catholic schools are Catholic enough.
Making up a substantial address book is fundamental because it facilitates the search for money, markets and associates, etc.
Similar(58)
And this would be a substantial addressing of our current carceral crisis.
Take your time to craft a substantial comment addressing a specific issue you can speak to personally, or that you've looked into enough to feel you have an informed opinion.
There is a substantial literature addressing the aetiology and treatment of ADHD, with studies examining the course of ADHD over time mostly focussed on children selected through clinical settings [ 9- 13].
The judge conducting an inquiry into the background of a disputed British intelligence dossier on Iraq's unconventional weapons was told today that the document underwent a "substantial rewrite" to address points raised by Prime Minister Tony Blair in the weeks before its publication last September.
"It is the view of the government that, despite the serious concerns you express, an inquest will go a substantial way to addressing or allaying public concern about this incident," she said.
The list of the class of 683 new members invited – including America Ferrera, Tina Fey, and Kate Beckinsale – to join the organization was released on Wednesday, a substantial step in addressing critiques over the Academy's lack of racial diversity, following a furor in January after no actors of color were nominated for any major awards for the second year in a row.
There is a substantial literature that addresses theoretical and empirical issues involved with inter market linkages among national stock indices.
The curricula of modern medical schools must address a substantial amount of scientific and clinical material in a limited time.
The one surviving letter to Shakespeare, from Richard Quyney, asking for a substantial loan of £30, addresses him as "loving countryman" - in the sense of a fellow native of Warwickshire.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com