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The phrase "a substance" is grammatically correct and can be used in written English.
It is typically used to refer to a physical material or matter that has definite properties and characteristics. Example: The scientist tested the unknown liquid to determine if it was a substance or just a mixture of chemicals.
Exact(59)
What sort of a substance was it?
'But there was a substance behind it.
This is a substance of abuse.
· Fat itself is a substance or essence of a substance or mode of that essence.
But there's a substance of anguish beneath the high style.
He was finally hired as a substance abuse counselor.
This is not a substance that has a threshold.
I began working as a substance abuse counselor.
A brown barrel containing a substance lay in the corner.
Alcohol is not, of course, a substance of milklike benignity.
As a substance, it's amazingly versatile for something so inert.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com