Remarkably, the CDKB-like sequences of O. tauri and C. reinhardtii have been reported to represent functional homologs of A-type CDKs, mainly by their ability to complement cdc28 temperature-sensitive yeast mutants [ 15, 17], indicating that B-type CDKs might originate from a duplication and subsequent specification of the A-type CDKs [ 18].
This process, which includes the specification of angioblasts towards venous and arterial fates, along with differential mechanisms of EC migration and subsequent specification within a tissue-specific niche, is highly relevant to our understanding of blood vessel formation and wiring during disease states and tissue regeneration.
Through functional genomics and genetic studies in mice, the functional role of some transcription factors in coordinating normal organogenesis and the subsequent specification into distinctive endocrine cell types got identified[38].
Further enhancement of β-cell differentiation may therefore be achieved by regulation of signals that promote or inhibit the initial differentiation of definitive endoderm specification from hES cells, and subsequent specification of the pancreatic lineages.
BMP-4 treatment induces Id4 expression along with translocation of OLIG1 and OLIG2 to the cytoplasm; therefore, it was proposed that cytoplasmic Id4 must reach a critical level to effectively sequester OLIG1 and OLIG2 to prevent their nuclear translocation, and subsequent specification of the cell fate [ 18].
Had the first article's section been intended as an open-ended authorization, such subsequent specifications would have made no sense.
Apparently, the real code developed stepwise following the classic scheme of gene duplications with subsequent specifications, regardless of whether it have started with a very specific stereo-chemical "key-lock", a true "frozen accident", or possibly something in between a "frozen stereo-chemical accident" ([ 16] see also [ 10]).
In subsequent specifications, we will allow different elasticities for the unemployment rate at origin and destination.
Subsequent specifications reported below add vectors of individual characteristics (X), individual unemployment duration (D), and state labor market characteristics (Z).
The 'Methodology of problem analysis' section has outlined the proposed multivariate DSS as subsequent specifications arising from the 'Case problem statement' section.
A subsequent Times dispatch adds.
