Exact(12)
This subgroup comprises about 1 in 6 patients, irrespective of whether it is the first or a subsequent relapse, and even when the delay between onset of first symptoms of relapse and initiation of treatment is brief.
Secondly, all subjects showed a subsequent relapse (defined as a sustained rise in PSA levels despite maximal treatment).
In our patient group after a 2 year disease-free interval the risk of developing non-small cell lung cancer seems higher than a subsequent relapse of SCLC.
EFS was calculated from date of relapse to occurrence of a subsequent relapse or death, and OS was calculated from date of relapse to death for any reason.
Eculizumab was used again in a subsequent relapse but there was progression to anuria and eculizumab was stopped after haemodialysis was started [ 8].
Nevertheless, in a proportion of patients, tumours are resistant to tamoxifen, or become so, with a subsequent relapse in the disease.
Similar(48)
Three of four patients who suffered an isolated CNS relapse developed a subsequent BM relapse and died.
Three of four patients (75%) who suffered an isolated CNS relapse developed a subsequent BM relapse and died, despite receiving cranial irradiation or allogeneic HSCT.
Findings highlight the economic impact of relapse and the importance of prior relapse as a predictor of subsequent relapse for clinicians and other health care decision makers.
These analyses show that the PCR assay of the bcr-abl fusion transcript 6 to 12 months post-BMT is an independent predictor of subsequent relapse which provides an opportunity for early therapeutic intervention.
To reassess optimal sequencing strategies, we performed ultra-deep (up to ∼312x) whole genome sequencing and exome capture (up to ∼433x) of a primary acute myeloid leukemia, its subsequent relapse, and a matched normal skin sample.
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