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All three patients had ILM and underwent a subsequent progression of disease (two local and one at distance).
Of 54 patients (58%) obtaining an initial biochemical response after two cycles, five patients (9%) experienced a subsequent progression in CA125 levels after three or four cycles.
We thus failed to observe a systematic pattern which would allow to conclude on an early site of lesion and a subsequent progression of pathology from one area to another.
This may be explained by the advent of early third relapses verified by the finding in 54 patients with initial response after two cycles, in which five patients (9%) experienced a subsequent progression in CA125 levels after three or four cycles.
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Our results suggest that vitamin D deficiency in UCTD patients may play a role in the subsequent progression into well-defined CTDs.
In a family study, frontal hypergyrification was confirmed in family members suffering from schizophrenia and in unaffected first-degree relatives compared with healthy control subjects [ 8] and in high-risk individuals for the development of schizophrenia increased right prefrontal lobe GI served as a predictor for the subsequent progression into schizophrenic disease [ 14].
A key step in subsequent progression to cancer is genomic instability, that occurs in about 5% of adenomas, either through failing DNA mismatch repair (ca. 0.5%, corresponding to 15% of all sporadic CRCs) giving rise to the mutator phenotype marked by microsatellite instability (MSI), or (ca. 4.5%, corresponding to 85% of all sporadic CRCs) (increased levels of) chromosomal instability (CIN).
Uniquely, higher urate levels in plasma or cerebrospinal fluid (CSF) have been linked to both a lower risk of developing PD and to a slower rate of its subsequent progression in numerous large prospective epidemiological and clinical cohorts.
In most cases a number of conserved arginine residues along S4 are predominantly responsible for the gating charge controlling the voltage-dependent conformational changes that lead to a concerted pore-opening transition of the channel from the resting state and its subsequent progression to a closed, inactivated state [3], [4], [5], [6], [7], [8], [9].
It is possible that MYH mutations may have a largely permissive role in tumorigenesis through polyp formation, with subsequent progression occurring as a result of changes to other key genes.
For other participants, hallucinations ceased for a period but returned with subsequent progression of their macular disease.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com