More importantly, the same doses of temporins, administered one week after experimental infection with a sub lethal dose of bacteria, sterilized 100% of the animals within 3 6 days.
The serum biochemical markers; alanine transaminase (ALT), lactate dehydrogenase (LDH) and creatine kinase (CK) increased after 6 h of administration of a sub lethal dose of the venom and remained significantly raised at 24 h.
In this study, we exposed C57BL/6J mice to 100 ppb As in drinking water for 5 weeks, followed by intranasal inoculation with a sub lethal dose of influenza A/PuertoRico/8/34 (H1N1) virus.
Antibiotic-treated SPF mice given a sub lethal dose of PR8 virus had impaired generation of virus specific antibody, cluster of differentiation 4+ (CD4+) and CD8+ T cell responses and delayed viral clearance 16.
Cells were then treated with a sub-cytotoxic dose of staurosporine at a dose of 0.25 or 0.5 μM for a further 24 h.
The injected dose of glycerol chosen is a sub-lethal dose.
TCRδ−/− (KO) and wild type (WT) C57BL/6 mice were infected either with a lethal dose of 10×LD50 or with a sub-lethal dose of.
In addition, a sub-effective dose of folic acid (1 nmol/site, i.c.v).
As 16 mg/ml was the LC50 dose (lethality data not presented), we used half of this dose, i.e., 8 mg/ml, as a sub-hyperkinetic dose for further developing and evaluating a chronic model.
However, sub-lethal doses of AA VK3 combination combined with a sub-toxic dose of α-TOS showed to induce efficient cell death that resembles autoschizis.
