Exact(23)
The assumption of no additional introductions from the outside into the household is particularly convenient, as it enabled us to obtain precise transmissibility estimates even with a study size of less than 50 households [23].
To compensate for possible exclusion, we chose a study size of 25 patients per group.
Given these estimates a study size of 170 patients per arm was chosen.
To detect a 10% difference, we calculated a study size of 200 patients to reach a 94% power.
Pre-study assessment of sample size, given an event rate of 10% in the CDW cohort, indicated a study size of 200 subjects in each cohort.
A study size of 300 patients also provided 95% confidence to conclude that if there were no serious events, the incidence of serious IRRs was < 1%.
Similar(37)
TEM distribution datapoint is based on the number of the particles in a studied size class whereas DLS distribution is based on the intensity of light that is scattered by the studied size class.
However, several methodological limitations including a small study size and a crude exposure assessment complicated the interpretation of these findings.
Nevertheless, several secondary endpoints have given encouraging results, despite limitations of a small study size and an inherent variability in quantitating immunohistochemical markers.
Further, it is a single centre study with a small study size, thus possibly limiting the generalisability of the results.
However, similarly to our study, a recent Korean study with a reasonable study size found the T-allele protective against COPD [ 41].
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