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Unless a study is randomized, rigorously controlled and published in a peer-reviewed journal, arm your bullshit meter if anyone is claiming they've found a scalable solution.
The important point is not whether a study is randomized or not, but whether it uses a method well suited to answer a question and whether it implements this method with optimal scientific rigor.
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A third study is randomizing 240 patients to 40 or 80 mg of simvastatin or placebo, with presence of DIDs listed as primary endpoint [120].
A third study is randomizing 240 patients to 40 or 80 mg of simvastatin or placebo, with presence of DIDs listed as primary endpoint [ 120].
The 21 case-management teams in this study were randomized in a 2 (EBP vs. services as usual [SAU]) by 2 (monitoring vs. no monitoring) design.
All adult participants in the 2005 study were randomized in a 1∶1 ratio to receive either TIV or LAIV.
Only a few studies were randomized and controlled trials [ 16, 17, 28- 30].
Both of these factors may have also affected heterogeneity if the studies were randomized with an active comparator.
All included studies were randomized.
All studies are randomized controlled.
Only a single comparison study, which is randomized, double-blind, and placebo-controlled, is available.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com