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Overall, a study including neurobiological measures may limit the research possibilities.
A study including 78 migraineurs and 208 healthy controls revealed that sleep quality and headache frequency was significantly associated after adjusting anxiety and depression [43].
Because of divergent results and limited number of participants in previous studies, a study including >50,000 participants should be of interest.
The findings are also supported by a case control study of episodic migraine [18, 20], as well as a study including 370 migraineurs and 119 non-migraineurs [20].
In this era of limited resources and cost savings in health care, a study including more than 100 patients would not be possible in our busy clinical practice.
Excluding the animal model setup, the required time for such a study including a final report is on the order of weeks.
Considering that DVT is more common [14], a study including both conditions could be insufficiently powered to confirm efficacy for PE.
This paper reports such a study including numerical evaluation of the codified methods of progressive collapses for precast concrete cross wall buildings.
In 2014, a study including the description of Zhanghenglong was published in the journal PLOS ONE.
Double blinding helps to practically eliminate all bias from a study, including from participants as well as the person performing the study.
A study including parallel sample testing would provide unbiased conclusions regarding clinical sensitivity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com