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Moreover, when a study includes many population samples that were not characterized by the same molecular typing methods, the existence of different ambiguity patterns in different population samples further increases the complexity of the data.
If a study includes a standardized and a non-standardized acupuncture arm, it would be useful to compare their cost-effectiveness.
This was easy for small sets of data, but is more difficult when a study includes thousands of sequenced genomes, with thousands of phenotypes or growth conditions and the integration of multiple "omics" data.
We agree that if a study includes only the first few years of screening dissemination without any post-screening follow-up that this can lead to overestimation, but most existing studies appropriately measure incidence during a screening and post-screening follow-up period and are thus able to measure overdiagnosis without this bias.
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Overall, a study including neurobiological measures may limit the research possibilities.
Other factors that affect the quality of a study include controls for smoking status, age and ethnicity -- something that low-quality studies did not do.
In 2014, a study including the description of Zhanghenglong was published in the journal PLOS ONE.
A study including parallel sample testing would provide unbiased conclusions regarding clinical sensitivity.
Interpretability was assessed in a study including 196 subjects[ 16].
A study including a broader sample of PHNs across varying contexts is warranted.
Therefore, our preliminary findings can only be generalizable with a study including a larger sample.
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