Sentence examples for a structural determination of from inspiring English sources

The 'form follows function' principle implies that a structural determination of protein structures is indispensable to understand proteins in their biological roles.

In the present study, we conducted a structural determination of the binding of full-length XPA to DNA-junctions.

To understand how this interaction occurs biochemically we implemented a structural determination of the interaction using a MS-based protein footprinting method and limited proteolysis.

A structural determination of the homologous prokaryotic enzyme, which exists as a homodimer, has given some insight into how disease mutations may affect the activity of the enzyme (8, 12).

A recent structural determination of the E. coli Dr adhesin bound to its human CEA receptor indicates that Dr also binds across the homo-dimer-forming surface of the receptor (Korotkova et al, 2008).

Here, an independent structural determination of the native human APC-1 regulatory domain was completed, which was combined with an investigation into the oligomeric state of the full-length human APC-1 protein.

Such subunit flexibility is analogous to a large crystallographic B-factor, making a high-resolution structural determination of the apo state impractical (Zhang et al, 2010).

Participants at a recent workshop on structural determination of environmentally responsive proteins convened by the National Institute of Environmental Health Sciences highlighted some of these technologies but cautioned that the greatest strides will come only from seeing the problems as more than just nails.

Structural determination of a metacaspase in the presence of a bound substrate and/or inhibitor has so far escaped elucidation and as a consequence the metacaspase S1-binding pocket cannot be mapped in the same way as the caspases.

Nevertheless, Buchwald and co-workers recently described the application of the crystalline sponge method, in conjunction with other analytical methods, for the structural determination of an electrophilic trifluoromethylthiolation reagent that was found to be a thioperoxide (Vinogradova et al., 2014 ▶).

In addition to its use as a tool for analysis and structural determination of molecules, there are many applications outside the laboratory.