Exact(23)
These parameters can be interpreted in a structural context, allow discrimination between different binding mechanisms and guide drug design.
The full-length V3-CTB presenting the complete V3 in a structural context mimicking gp120 was recognized by the large majority of our panel of 24 mAbs.
This paper builds on the work in tracking modes in a structural context, using the Modal Assurance Criterion (MAC) to numerically relate modes from two comparable linear systems.
The failure on the part of current control efforts to assimilate such a structural context may render even an efficacious vaccine dysfunctional.
The structures of CifPl and CifBp also present an opportunity to put the remaining four conserved residues into a structural context: Asn70, Asp76, Ile94 and Gly103 (CifPl numbering, Asn36/Asp42/Ile60/Gly69 in CifBp and Asn52/Asp58/Ile76/Gly88 in CifEc).
The high resolution structures of LeuT [10] [15], a prokaryotic homolog of DAT, have provided essential structural insights that can serve to interpret the results of experimental investigations of DAT in a structural context [16], but offer only limited clues about the molecular mechanism of transport.
Similar(37)
Thus, we developed a selection system that enables the identification of novel RNA motifs that interact with a target RNA structure within a desired structural context.
To develop such RNA tools, we applied an artificial ligase ribozyme (Designed-and-Selected Ligase, DSL; Ikawa et al. 2002) to develop a selection system to generate novel RNA receptor motifs against a target RNA structure within a given structural context (Ohuchi et al. 2008).
Non-QSOX Erv domains have these same two functional residues, but in a simpler structural context: they are present in a KXXF/Y motif on the approximately ten-residue linker that directly connects the fourth and fifth helix in the Erv bundle.
Equal intragenic crossing-over results in domain swaps between genes whereas unequal crossing-over influences the number of genes within a locus and potentially places genes into a new structural context.
The structure of HbpA allows the beneficial mutation sites previously identified to be put into a tertiary structural context for the first time, and also provides a robust platform for further protein engineering of this useful enzyme.
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