Sentence examples for a stronger efficacy from inspiring English sources

Due to this unfavourable situation, recent approaches to gain a stronger efficacy against melanoma focused on new target-directed therapeutic strategies.

In phase I studies in patients with advanced solid tumours, volasertib (BI 6727), an additional dihydropteridinone derivative with an improved PK profile compared with BI 2536, has provided a stronger efficacy signal than BI 2536 and a favourable safety profile (Schöffski et al, 2012).

The ideal proof-of-principle study design provides a strong efficacy signal over the shortest duration, while exposing the fewest patients possible.

Results showed a strong efficacy of the tested compounds, even at the lower doses, in counteracting the induced oxidative stress (50 μM of H2O2) and in preventing ROS formation.

A strong efficacy component to enable efforts to reduce risk is also needed.

The summary result favored a strong efficacy of decreased Fg to bring about PHI (OR, 3.44 95% CI, 2.37 4.99; P < 0.001).

The siRNA formulation was widely distributed, delivering the siRNA to several organs with a strong efficacy in the liver and spleen.

Against the INT-ACP/PTX human tumour xenograft, the dose of 2 × 90 mg kg−1 (twice a day) showed only a partial efficacy, whereas a strong efficacy (96% TWI) was achieved by a daily injection of 180 mg kg−1.

Silibinin, a flavonoid from milk thistle seed extract, is a widely consumed dietary supplement that shows a strong efficacy both in vitro and in vivo against prostate cancer, establishing also its implication on epithelial mesenchymal transition [ 90– 92].

97– 99 Despite the advantage of a strong efficacy profile with the application of terbinafine for one week, efforts to simplify topical administration, decrease treatment duration and improve compliance has lead to the development of a polymeric film-forming solution (FFS) designed as a "one-time" dose.

However, based on their different in vitro IC50 values towards CK2 (also shown in Figure 1, box), a much stronger efficacy of CX-4945 was expectable.